Tools for microdosing powders for Dry Powder Inhalers and precise dosing.

The dosing principle is called tamping pin method. The tamping pin principle is applied like so: powder is compacted step by step in the dosing volume until a plug of defined density is formed, which is then transferred into the receptacle.

For crystalline powders, the RSD is typically 2% or less. Cohesive powders are somewhat more challenging, but deviations generally do not exceed 3%. The accuracy also depends to some extent on the operator’s skill. The new electrically actuated SAK-1 eliminates this human factor, ensuring even more consistent results. Overall, the dosing accuracy of Miccados devices is more than sufficient and fully comparable to that of other laboratory dosing systems.

The original mechanical SAK-1 was developed with the ambition of creating the simplest possible micro-dosing device. It operates purely mechanically, without the need for auxiliary media such as electricity or compressed air. Due to its robust construction, it is virtually indestructible (although it is not recommended to run a steamroller over it, as this could damage the steamroller). The device can remain unused for months and still be immediately operational. The mechanical version is particularly suited for non-GMP environments, where conditions may be less controlled.

The electrical version incorporates several additional features. The descent of the tamping pin is controlled by an electric motor, ensuring reproducibility and eliminating the human factor, thereby reducing variability between doses. Once parameters are set, consistent results are achieved regardless of operator. Descent speed of the tamping pin can be finely adjusted via a rotary dial, and integrated sensors monitor device status and prevent handling errors. This version is therefore the preferred choice when larger quantities are required. Documentation is also facilitated, as device parameters are clearly defined, making validation straightforward. Consequently, the electrical variant is particularly suitable for GMP-regulated applications, such as the manufacture of clinical trial samples. The trade-off is that it requires electrical power (24 V, supplied by a removable power bank) as well as a controller board and software, which make qualification and operation somewhat more complex.